The Proparation and Long-term Storage Stability of Carbomer Loaded Polydatin Nanocrystals Hydrogels

This work aims to develop carbomer (934, 0.25%) loaded polydatin nanocrystals hydrogel (Pol-NaH) as a novel dermal formulation..Polydatin nanocrystals were prepared by high pressure homogenization technique, applying 1500 bar up to 15 cycles. The long-term storage stability of Pol-NaH was studied after stored at room temperature for 180 days. The physicochemical characteristics of Pol-NaH were conducted and used to evaluate the stability. The results showed that the particle size (PS), polydispersity index (PDI) and zeta potential (ZP) were 188.3±3.7 nm, 0.193±0.041 and −12.67±0.91 mV, respectively. After six months of storage, the Pol-NaH showed no significant changes in PS and PDI except a miner change in ZP. These results demonstrate that Pol-NaH could be a promising formulation for enhanced pharmacological activity of polydatin and were stable at at room temperature.